Chauhan, Navya ; Pradhan, Sajan ; Ghorai, Manas K (2019) Stereospecific Synthesis of Highly Substituted Piperazines via an One-Pot Three Component Ring-Opening Cyclization from N-Activated Aziridines, Anilines, and Propargyl Carbonates The Journal of Organic Chemistry, 84 (4). pp. 1757-1765. ISSN 0022-3263
Full text not available from this repository.
Official URL: http://doi.org/10.1021/acs.joc.8b02259
Related URL: http://dx.doi.org/10.1021/acs.joc.8b02259
Abstract
A simple and efficient one-pot three-component synthetic route to highly substituted and functionalizable piperazines in high yields with excellent stereoselectivity (de, ee >99%) is reported. The SN2-type ring-opening of N-activated aziridines by anilines followed by Pd-catalyzed annulation with propargyl carbonates gives rise to the final piperazine products.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 117081 |
| Deposited On: | 15 Apr 2021 07:41 |
| Last Modified: | 15 Apr 2021 07:41 |
Repository Staff Only: item control page
