Argonautes and Company: Sailing against the Wind

Bhattacharyya, Suvendra N. ; Filipowicz, Witold (2007) Argonautes and Company: Sailing against the Wind Cell, 128 (6). pp. 1027-1028. ISSN 0092-8674

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The 3'-untranslated region (UTR) of mRNA is crucial for posttranscriptional regulation. In this issue, Vasudevan and Steitz (2007) report a new function for AGO2 and FXR1--two proteins that have been linked to the regulation of microRNAs and translation repression. AGO2 and FXR1 bind to the AU-rich element in the 3'-UTR of TNFalpha mRNA, unexpectedly activating its translation in a cell growth-dependent manner.

Item Type:Article
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