Sundriyal, Sandeep ; Khanna, Smriti ; Saha, Rikta ; Bharatam, Prasad V. (2008) Metformin and glitazones: does similarity in biomolecular mechanism originate from tautomerism in these drugs? Journal of Physical Organic Chemistry, 21 (1). pp. 30-33. ISSN 0894-3230
Full text not available from this repository.
Official URL: http://doi.org/10.1002/poc.1273
Related URL: http://dx.doi.org/10.1002/poc.1273
Abstract
his theoretical study attempts to find out similarity between metformin and glitazone class of antidiabetic drugs. It was found that some tautomeric forms of both metformin and thiazolidinedione ring of glitazones have similar molecular electrostatic potential (MESP) surface and may bind to a common complementary surface. Complexation and docking studies were also carried out in order to support this hypothesis.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley & Sons, Inc. |
| Keywords: | Metformin; Glitazones; Tautomerism; Mechanism of Action; PPARγ; AMPK. |
| ID Code: | 116602 |
| Deposited On: | 12 Apr 2021 10:19 |
| Last Modified: | 12 Apr 2021 10:19 |
Repository Staff Only: item control page
