Possibility of the Existence of Donor–Acceptor Interactions in Bis(azole)amines: An Electronic Structure Analysis

Bhatia, Sonam ; Bharatam, Prasad V. (2014) Possibility of the Existence of Donor–Acceptor Interactions in Bis(azole)amines: An Electronic Structure Analysis The Journal of Organic Chemistry, 79 (11). pp. 4852-4862. ISSN 0022-3263

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Official URL: http://doi.org/10.1021/jo402862r

Related URL: http://dx.doi.org/10.1021/jo402862r

Abstract

Donor-stabilized divalent N(I) systems have recently gained attention in the field of organic chemistry. Existence of low-valent nitrogen(I) species with moderate nucleophilicities in several pharmacophoric functionalities is prompting extensive exploration in this field. Quantum chemical analysis on the imidazole, oxazole, and thiazole derivatives of thiazole-2-amine indicated that these species preferably exist in the iminic state. Electronic structure analysis of these systems suggested the existence of hidden divalent N(I) character in a neutral state (L → N–R) and the explicit divalent N(I) character (L → N ← L)+ in the protonated state. The strength of L → N interaction in these systems was analyzed, and the variations in the nucleophilicity trend at the coordinating nitrogen center were rationalized by estimating the electronic (TEP (Tolman electronic parameter) and MESP minimum (Vmin)) as well as steric parameters (r-repulsiveness and ΔH elimination of CO group, in L → Ni(CO)3) of the coordinating ligands L. The importance of energetically preferred ionic and tautomeric representations of thiazol-2-amine derivatives in iminic and aminic forms was also demonstrated by carrying out comparative docking analysis with the enzyme lymphocyte-specific kinase (Lck).

Item Type:Article
Source:Copyright of this article belongs to American Chemical Society.
ID Code:116448
Deposited On:12 Apr 2021 09:43
Last Modified:12 Apr 2021 09:43

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