Kurmi, Moolchand ; Patel, Neha ; Jhajra, Shalu ; Bharatam, Prasad V. ; Singh, Saranjit (2017) Characterization of forced degradation products of torasemide through MS tools and explanation of unusual losses observed during mass fragmentation of drug and degradation products through density functional theory Journal of Pharmaceutical and Biomedical Analysis, 145 . pp. 209-218. ISSN 0731-7085
Full text not available from this repository.
Official URL: http://doi.org/10.1016/j.jpba.2017.06.015
Related URL: http://dx.doi.org/10.1016/j.jpba.2017.06.015
Abstract
Mass spectrometry tools (HRMS/LC-HRMS, MSn, and/or on-line H/D exchange) were employed to establish mass fragmentation pattern of torasemide and to characterize its degradation products. During collision-induced dissociation, multiple rearrangement processes and unusual losses of sulfur (S), sulfanyl (HSradical dot), sulfur dioxide (SO2), sulphinic acid radical (HSO2radical dot), sulfur monoxide (SO), carbon monoxide (CO), formyl radical (CHOradical dot) and C5H3NOS were observed. The same were successfully explained by study of energy profiles, established by application of density functional theory (DFT).
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier B.V. |
| Keywords: | Torasemide; Fragmentation Behaviour; Degradation Product; High Resolution Mass Spectrometry; Multi-stage Mass Spectrometry; Density Functional Theory. |
| ID Code: | 116325 |
| Deposited On: | 12 Apr 2021 09:24 |
| Last Modified: | 12 Apr 2021 09:24 |
Repository Staff Only: item control page
