Kour, Jaspreet ; Venkateswarlu, Vunnam ; Verma, Praveen K. ; Hussain, Yaseen ; Dubey, Gurudutt ; Bharatam, Prasad V. ; Sahoo, Subash C. ; Sawant, Sanghapal D. (2020) Oxone-DMSO Triggered Methylene Insertion and C(sp2)−C(sp3)-H−C(sp2) Bond Formation to Access Functional Bis-Heterocycles The Journal of Organic Chemistry, 85 (7). pp. 4951-4962. ISSN 0022-3263
Full text not available from this repository.
Official URL: http://doi.org/10.1021/acs.joc.9b03477
Related URL: http://dx.doi.org/10.1021/acs.joc.9b03477
Abstract
Metal-free insertion of a methylene group was achieved for the construction of a new C(sp2)–C(sp3)-H–C(sp2) bond in order to prepare novel bis-heterocyclic scaffolds. The complete mechanistic investigations included experimental study and DFT calculations, and various symmetric and unsymmetric bis-pyrazoles as well as other pyrazole-based bis-heterocyclic molecules were prepared in moderate to high yields. Further modification of the bridged methylene group in the unsymmetric pyrazoles generated a chiral center to extend the scope of this method.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 116259 |
| Deposited On: | 12 Apr 2021 09:15 |
| Last Modified: | 12 Apr 2021 09:15 |
Repository Staff Only: item control page
