A new microscopic insight into membrane penetration and reorganization by PETIM dendrimers

Bhattacharya, R. ; Kanchi, Subbarao ; C., Roobala ; Lakshminarayanan, A. ; Seeck, Oliver H. ; Maiti, Prabal K. ; Ayappa, K. G. ; Jayaraman, N. ; Basu, J. K. (2014) A new microscopic insight into membrane penetration and reorganization by PETIM dendrimers Soft Matter, 10 (38). pp. 7577-7587. ISSN 1744-683X

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Official URL: http://doi.org/10.1039/C4SM01112K

Related URL: http://dx.doi.org/10.1039/C4SM01112K

Abstract

Dendrimers are highly branched polymeric nanoparticles whose structure and topology, largely, have determined their efficacy in a wide range of studies performed so far. An area of immense interest is their potential as drug and gene delivery vectors. Realizing this potential, depending on the nature of cell surface-dendrimer interactions, here we report controlled model membrane penetration and reorganization, using a model supported lipid bilayer and poly(ether imine) (PETIM) dendrimers of two generations. By systematically varying the areal density of the lipid bilayers, we provide a microscopic insight, through a combination of high resolution scattering, atomic force microscopy and atomistic molecular dynamics simulations, into the mechanism of PETIM dendrimer membrane penetration, pore formation and membrane re-organization induced by such interactions. Our work represents the first systematic observation of a regular barrel-like membrane spanning pore formation by dendrimers, tunable through lipid bilayer packing, without membrane disruption.

Item Type:Article
Source:Copyright of this article belongs to Royal Society of Chemistry.
ID Code:116092
Deposited On:22 Mar 2021 07:06
Last Modified:22 Mar 2021 07:06

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