Supramolecular Reassembly of Self‐Exfoliated Ionic Covalent Organic Nanosheets for Label‐Free Detection of Double‐Stranded DNA

Mal, Arindam ; Mishra, Rakesh K. ; Praveen, Vakayil K. ; Khayum, M. Abdul ; Banerjee, Rahul ; Ajayaghosh, Ayyappanpillai (2018) Supramolecular Reassembly of Self‐Exfoliated Ionic Covalent Organic Nanosheets for Label‐Free Detection of Double‐Stranded DNA Angewandte Chemie International Edition, 57 (28). pp. 8443-8447. ISSN 1433-7851

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Official URL: http://doi.org/10.1002/anie.201801352

Related URL: http://dx.doi.org/10.1002/anie.201801352

Abstract

Ionic covalent organic nanosheets (iCONs), a member of the two‐dimensional (2D) nanomaterials family, offer a unique functional platform for a wide range of applications. Herein, we explore the potential of an ethidium bromide (EB)‐based covalent organic framework (EB‐TFP) that self‐exfoliates in water resulting in 2D ionic covalent organic nanosheets (EB‐TFP‐iCONs) for the selective detection of double‐stranded DNA (dsDNA). In an aqueous medium, the self‐exfoliated EB‐TFP‐iCONs reassemble in the presence of dsDNA resulting in hybrid EB‐TFP‐iCONs‐DNA crystalline nanosheets with enhanced fluorescence at 600 nm. Detailed steady‐state and time‐resolved emission studies revealed that the reassembly phenomenon was highly selective for dsDNA when compared to single‐stranded DNA (ssDNA), which allowed us to use the EB‐TFP‐iCONs as a 2D fluorescent platform for the label‐free detection of complementary DNA strands.

Item Type:Article
Source:Copyright of this article belongs to John Wiley & Sons, Inc..
Keywords:DNA; Covalent Organic Framework; Ionic Assembly; Ionic Covalent Organic Nanosheets; label-Free Detection.
ID Code:115741
Deposited On:16 Mar 2021 07:47
Last Modified:16 Mar 2021 07:47

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