Peripheral blood mononuclear cells of patients with Indian visceral leishmaniasis suppress natural killer cell activity in vitro

Chakrabarti, Ganes ; Basu, Anirban ; Pratim Manna, Partha ; Bhattacharya, Sumitra ; Sen, Sandeep ; Bandyopadhyay, Santu (1996) Peripheral blood mononuclear cells of patients with Indian visceral leishmaniasis suppress natural killer cell activity in vitro Transactions of the Royal Society of Tropical Medicine and Hygiene, 90 (5). pp. 582-585. ISSN 0035-9203

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Official URL: http://doi.org/10.1016/S0035-9203(96)90333-8

Related URL: http://dx.doi.org/10.1016/S0035-9203(96)90333-8

Abstract

Peripheral blood mononuclear cells (PBMC) of patients with Indian visceral leishmaniasis (VL) suppressed the natural killer cell (NK) activity of normal human PBMC in vitro in a dose-dependent manner. Adherent monocytes, but not the non-adherent lymphocytes of VL patients suppressed NK activity through soluble mediators. The level of suppression seen in different patients was variable.

Item Type:Article
Source:Copyright of this article belongs to Oxford University Press.
Keywords:Visceral Leishmaniasis; Leishmania Donovani; Post Kala-azar Dermal Leishmaniasis; Peripheral Blood Mononuclear Cells; Natural Killer Cell Activity.
ID Code:115693
Deposited On:18 Mar 2021 04:54
Last Modified:18 Mar 2021 04:54

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