Interleukin-1: A master regulator of neuroinflammation

Basu, Anirban ; Krady, J. Kyle ; Levison, Steven W. (2004) Interleukin-1: A master regulator of neuroinflammation Journal of Neuroscience Research, 78 (2). pp. 151-156. ISSN 0360-4012

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Interleukins 1α and 1β (IL‐1) are very potent signaling molecules that are expressed normally at low levels, but are induced rapidly in response to local or peripheral insults. IL‐1 coordinates systemic host defense responses to pathogens and to injury and not surprisingly it has similar effects within the central nervous system (CNS). Numerous reports have correlated the presence of IL‐1 in the injured or diseased brain, and its effects on neurons and nonneuronal cells in the CNS, but it is only recently that the importance of IL‐1 signaling has been recognized. This article reviews studies that demonstrate that IL‐1 is at or near the top of the hierarchical cytokine signaling cascade in the CNS that results in the activation of endogenous microglia and vascular endothelial cells to recruit peripheral leukocytes (i.e., neuroinflammation). The IL‐1 system thus provides an attractive target for therapeutic intervention to ameliorate the destructive consequences of neuroinflammation.

Item Type:Article
Source:Copyright of this article belongs to John Wiley & Sons.
Keywords:Cytokines; Central Nervous System; Stroke; Multiple Sclerosis; Alzheimer's Disease; Microglia; Astrocytes.
ID Code:115684
Deposited On:18 Mar 2021 04:47
Last Modified:18 Mar 2021 04:47

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