RIG-I knockdown impedes neurogenesis in a murine model of Japanese encephalitis

Mukherjee, Sriparna ; Ghosh, Sourish ; Nazmi, Arshed ; Basu, Anirban (2014) RIG-I knockdown impedes neurogenesis in a murine model of Japanese encephalitis Cell Biology International, 39 (2). pp. 224-229. ISSN 1065-6995

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Official URL: http://doi.org/10.1002/cbin.10354

Related URL: http://dx.doi.org/10.1002/cbin.10354

Abstract

Retinoic acid inducible gene I (RIG‐I) is a well established pattern recognition receptor (PRR) in neurons infected with Japanese encephalitis virus (JEV) as reported previously from our laboratory. Japanese encephalitis (JE) virus infection in brain has been shown to decrease the proliferation of neural stem/progenitor cells (NSPCs) which has its implications in neurological sequelae in JE survivors. We have found that ablation of RIG‐I both in vivo and in vitro models results in significant decrease in NSPC proliferation post JEV infection. We hypothesize that knockdown of RIG‐I diminishes the expression of antiviral molecules resulting in an increase in viral replication, which in turn results in enhancement of the expression of cell cycle inhibitors, hence affecting the proliferation of NSPCs.

Item Type:Article
Source:Copyright of this article belongs to John Wiley & Sons.
Keywords:Japanese Encephalitis Virus; Morpholino; Neurogenesis; Neural Stem/Progenitor Cells (Nspc); Retinoic Acid Inducible Gene I (Rig‐i); Knockdown.
ID Code:115545
Deposited On:17 Mar 2021 11:39
Last Modified:17 Mar 2021 11:39

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