Trigger-responsive engineered-nanocarriers and image-guided theranostics for rheumatoid arthritis

Ahamad, Nadim ; Prabhakar, Ameya ; Mehta, Sourabh ; Singh, Ekta ; Bhatia, Eshant ; Sharma, Shivam ; Banerjee, Rinti (2020) Trigger-responsive engineered-nanocarriers and image-guided theranostics for rheumatoid arthritis Nanoscale, 12 (24). pp. 12673-12697. ISSN 2040-3364

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Official URL: http://doi.org/10.1039/D0NR01648A

Related URL: http://dx.doi.org/10.1039/D0NR01648A

Abstract

Rheumatoid Arthritis (RA), one of the leading causes of disability due to progressive autoimmune destruction of synovial joints, affects ∼1% of the global population. Standard therapy helps in reducing inflammation and delaying the progression of RA but is limited by non-responsiveness on long-term use and several side-effects. The conventional nanocarriers (CNCs), to some extent, minimize toxicity associated with free drug administration while improving the therapeutic efficacy. However, the uncontrolled release of the encapsulated drug even at off-targeted organs limits the application of CNCs. To overcome these challenges, trigger-responsive engineered nanocarriers (ENCs) have been recently explored for RA treatment. Unlike CNCs, ENCs enable precise control over on-demand drug release due to endogenous triggers in arthritic paws like pH, enzyme level, oxidative stress, or exogenously applied triggers like near-infrared light, magnetic field, ultrasonic waves, etc. As the trigger is selectively applied to the inflamed joint, it potentially reduces toxicity at off-target locations. Moreover, ENCs have been strategically coupled with imaging probe(s) for simultaneous monitoring of ENCs inside the body and facilitate an ‘image-guided-co-trigger’ for site-specific action in arthritic paws. In this review, the progress made in recently emerging ‘trigger-responsive’ and ‘image-guided theranostics’ ENCs for RA treatment has been explored with emphasis on the design strategies, mechanism, current status, challenges, and translational perspectives.

Item Type:Article
Source:Copyright of this article belongs to Royal Society of Chemistry.
ID Code:115197
Deposited On:17 Mar 2021 03:31
Last Modified:17 Mar 2021 03:31

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