Cloning and sequence analysis of b-tubulin gene of Trypanosoma evansi isolates from Indian dromedaries (Camelus dromedarius)

Ashraf, M. ; Srivastava, Meera ; Ghorui, S. K. ; Nagarajan, G. ; Swami, Shelesh Kumar ; Kumar, Sanjay (2015) Cloning and sequence analysis of b-tubulin gene of Trypanosoma evansi isolates from Indian dromedaries (Camelus dromedarius) Indian Journal of Animal Research (OF). ISSN 0367-6722

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Official URL: http://doi.org/10.18805/ijar.5573

Related URL: http://dx.doi.org/10.18805/ijar.5573

Abstract

Trypanosomosis caused by Trypanosoma evansi is a disease of economic significance of domestic livestock, causing trypanosomiasis, commonly known as Surra. In the present study, gene of Trypanosoma evansi have beer cloned and sequenced. Beta-tubulin is important for cellular structure and physical functions. Sequence analysis of this gene will be useful for the vaccine studies. The open reading frame of b-tubulin of Trypanosoma evansi is 1329 bp in length, encoding 442 amino acid polypeptide. The sequence analysis revealed that the ß tubulin gene of Trypanosoma evansi from India was having the identity of 99% with T.equiperdum, T.evansi (China isolate), T.evansi (Indian isolates), T.brucei and 88% with T.cruzi. The stable biological characteristics of Trypanosomatidae beta-tubulin make it an ideal target of many anti-parasitic drugs that block tubulin function.

Item Type:Article
Source:Copyright of this article belongs to Agricultural Research Communication Centre.
Keywords:ß tubulin Gene;Dromedarian Camel;Phylogenetic Analysis;T. Evansi.
ID Code:115188
Deposited On:16 Mar 2021 11:32
Last Modified:16 Mar 2021 11:32

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