Sharma, Swati ; Garg, Iti ; Ashraf, Mohammad Z (2016) TLR signalling and association of TLR polymorphism with cardiovascular diseases Vascular Pharmacology, 87 . pp. 30-37. ISSN 15371891
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Official URL: http://doi.org/10.1016/j.vph.2016.10.008
Related URL: http://dx.doi.org/10.1016/j.vph.2016.10.008
Abstract
Toll-Like receptors (TLRs) are the primary receptors of innate immunity. Considerable evidences have shown that innate immune defence interaction with pro-inflammatory pathways could be through TLRs that in turn leads to development of inflammatory diseases. These TLRs are present on various tissues and cells of cardiovascular system. Previous studies involving SNPs analysis of TLRs demonstrated that TLRs are involved in development and progression of diseases like atherosclerosis, cardiac dysfunction in sepsis and congestive heart failure. In this review, we aimed to bring together the studies which have been conducted previously to establish a link between TLR polymorphism in context to development of cardiovascular diseases (CVD).
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier B.V. |
| Keywords: | Toll-like Receptors (TLRs); TLR Polymorphism; Cardiovascular Diseases; Atherosclerosis. |
| ID Code: | 115091 |
| Deposited On: | 16 Mar 2021 10:27 |
| Last Modified: | 16 Mar 2021 10:27 |
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