Prediction of separation factor in foam separation of proteins

Bhattacharjee, Samita ; Kumar, R. ; Gandhi, K. S. (1997) Prediction of separation factor in foam separation of proteins Chemical Engineering Science, 52 (24). pp. 4625-4636. ISSN 0009-2509

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A phenomenological model has been developed for predicting separation factors obtained in concentrating protein solutions using batch-foam columns. The model considers the adsorption of surface active proteins onto the air-water interface of bubbles, and drainage of liquid from the foam, which are the two predominant processes responsible for separation in foam columns. The model has been verified with data collected on casein and bovine serum albumin (BSA) solutions, for which adsorption isotherms are available in the literature. It has been found that an increase in liquid pool height above the gas distributor and the time allowed for drainage result in a better separation. Further, taller foam columns yield poorer separation at constant time of drainage. The model successfully predicts the observed results.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Foam; Separation; Proteins
ID Code:11501
Deposited On:16 Nov 2010 13:52
Last Modified:02 Jun 2011 05:03

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