Interaction between antitumor antibiotic chromomycin A3 and Mg2+. I. Evidence for the formation of two types of chromomycin A3-Mg2+ complexes

Aich, Palok ; Sen, Ranjan ; Dasgupta, Dipak (1992) Interaction between antitumor antibiotic chromomycin A3 and Mg2+. I. Evidence for the formation of two types of chromomycin A3-Mg2+ complexes Chemico-Biological Interactions, 83 (1). pp. 23-33. ISSN 0009-2797

Full text not available from this repository.

Official URL: https://www.sciencedirect.com/science/article/pii/...

Related URL: http://dx.doi.org/10.1016/0009-2797(92)90089-4

Abstract

Chromomycin A3 (CHRA3) is an antitumor antibiotic which binds to Mg2+. In the present communication, we show, by means of equilibrium spectroscopic studies (such as absorption, fluorescence and circular dichroism), that two types of CHRA3- Mg2+ complexes (of 1:1 and 1.9:1 stoichiometries in terms of CHRA3: Mg2+ respectively) are formed depending on the concentrations of CHRA3 and Mg2+. The rate constant and activation energy for the formation of two complexes are different, thereby reinforcing the proposition that they are different molecular species. This observation is novel and significant in order to understand the anticancer property of the drug. It also provides explanation for earlier observations that site, affinity parameters and mode of interaction of the drug with DNA in the presence of Mg2+ depend on the relative concentration of Mg2+.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Antitumor Antibiotic; Chromomycin A3; Magnesium Ion; Stoichiometry; Circular Dichroism; Fluorescence; Kinetics
ID Code:114800
Deposited On:04 Jun 2018 06:18
Last Modified:04 Jun 2018 06:18

Repository Staff Only: item control page