Rho Protein: Roles and mechanisms

Mitra, Pallabi ; Ghosh, Gairika ; Hafeezunnisa, Md. ; Sen, Ranjan (2017) Rho Protein: Roles and mechanisms Annual Review of Microbiology, 71 (1). pp. 687-709. ISSN 0066-4227

Full text not available from this repository.

Official URL: https://www.annualreviews.org/doi/10.1146/annurev-...

Related URL: http://dx.doi.org/10.1146/annurev-micro-030117-020432


At the end of the multistep transcription process, the elongating RNA Polymerase (RNAP) is dislodged from the DNA template either at specific DNA sequences, called the terminators, or by a nascent RNA-dependent helicase, Rho. In Escherichia coli, about half of the transcription events are terminated by the Rho protein. Rho utilizes its RNA-dependent ATPase activities to translocate along the mRNA and eventually dislodges the RNAP via an unknown mechanism. The transcription elongation factor NusG facilitates this termination process by directly interacting with Rho. In this review, we discuss current models describing the mechanism of action of this hexameric transcription terminator, its regulation by different cis and trans factors, and the effects of the termination process on physiological processes in bacterial cells, particularly E. coli and Salmonella enterica Typhimurium.

Item Type:Article
Source:Copyright of this article belongs to Annual Reviews.
Keywords:RNA Polymerase; Rho; Nusg; Nusa; Transcription Termination; Psu
ID Code:114742
Deposited On:04 Jun 2018 06:11
Last Modified:04 Jun 2018 06:11

Repository Staff Only: item control page