Effect of atorvastatin and pioglitazone on plasma levels of adhesion molecules in non-diabetic patients with hypertension or stable angina or both

Pattan, Vishwanath ; Jehangir, Waqas ; Seth, Sandeep ; Bhargava, Balram ; Maulik, Subir Kumar (2015) Effect of atorvastatin and pioglitazone on plasma levels of adhesion molecules in non-diabetic patients with hypertension or stable angina or both Journal of Clinical Medicine Research, 7 (8). pp. 613-619. ISSN 1918-3003

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Official URL: http://www.jocmr.org/index.php/JOCMR/article/view/...

Related URL: http://dx.doi.org/10.14740/jocmr2178e

Abstract

Background: It was to study the effect of atorvastatin, pioglitazone and their combination on plasma levels of adhesion molecules in patients with hypertension or stable angina or both. Methods: It was an open-label, randomized parallel-group study. Forty-five atorvastatin-naive patients with hypertension or stable angina or both, were randomized to receive either atorvastatin (19 patients; 10 mg OD for 12 weeks) or pioglitazone (26 patients; 30 mg OD for 12 weeks). Another group of 30 patients who were already on atorvastatin were put on add-on pioglitazone therapy (pioglitazone (15 mg OD) + atorvastatin (10 mg OD) for 12 weeks). Plasma high-sensitivity C-reactive protein (hsCRP), soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) levels were measured at baseline and after 12 weeks of therapy. Results: Atorvastatin monotherapy significantly reduced plasma sICAM-1, but pioglitazone monotherapy did not produce any significant effect. Addition of pioglitazone in patients already receiving atorvastatin also significantly reduced plasma sICAM-1 level. However, there was no significant change in plasma hsCRP and sVCAM-1 levels in any of the groups after 12 weeks of therapy. Conclusion: There is therapeutic advantage of combining pioglitazone and atorvastatin on plasma sICAM-1 levels.

Item Type:Article
Source:Copyright of this article belongs to Elmer Press.
Keywords:hsCRP; sICAM-1; sVCAM-1; Atorvastatin; Pioglitazone
ID Code:114568
Deposited On:01 Jun 2018 08:54
Last Modified:01 Jun 2018 08:54

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