A new route to (±) metoprolol

Gurjar, M. K. ; Joshi, Shreerang V. ; Sastry, B. S. ; Rama Rao, A. V. (1990) A new route to (±) metoprolol Synthetic Communications, 20 (22). pp. 3489-3496. ISSN 0039-7911

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Related URL: http://dx.doi.org/10.1080/00397919008051592


Synthesis of 4-(2-methoxyethyl)phenol (5) from phenol is described. The derived aryloxyallyl ether (6) is converted into (±)-metoprolol (10) by involving dihydroxylation reaction with OsO4 and NMO.

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