Chavan, Subhash P. ; Khobragade, Dushant A. ; Kamat, Subhash K. ; Sivadasan, Latha ; Balakrishnan, Kamalam ; Ravindranathan, T. ; Gurjar, Mukund K. ; Kalkote, Uttam R. (2004) An efficient and green protocol for the preparation of cycloalkanols: a practical synthesis of venlafaxine Tetrahedron Letters, 45 (39). pp. 7291-7295. ISSN 0040-4039
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...
Related URL: http://dx.doi.org/10.1016/j.tetlet.2004.08.018
Abstract
The condensation of arylacetonitriles with cyclic ketones using aqueous NaOH or KOH under phase transfer catalysis gives almost quantitative yields of cycloalkanols. This protocol is utilized for a practical synthesis of the antidepression drug, venlafaxine 1.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Condensation; Cycloalkanols; Phase Transfer Catalyst |
| ID Code: | 11447 |
| Deposited On: | 09 Nov 2010 06:13 |
| Last Modified: | 02 Jun 2011 09:46 |
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