Spermidine induced aggregation of terphenyl derivative: An efficient probe for detection of spermidine in living cells

Tejpal, Ruchi ; Kumar, Manoj ; Bhalla, Vandana (2018) Spermidine induced aggregation of terphenyl derivative: An efficient probe for detection of spermidine in living cells Sensors and Actuators B: Chemical, 258 . pp. 841-849. ISSN 0925-4005

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Official URL: https://www.sciencedirect.com/science/article/pii/...

Related URL: http://dx.doi.org/10.1016/j.snb.2017.11.123

Abstract

A terphenyl derivative 3 has been designed and synthesized which undergoes self-assembly in mixed aqueous media to form weakly emissive aggregates. Aggregates of derivative 3 selectively detect spermidine and exhibit spermidine-induced emission enhancement. The interactions between aggregates of derivative 3 and spermidine result in the formation of AIE- active Schiff base adduct 4. In principle, the formation of Schiff base adduct 4 through the reaction of aldehyde groups present on aggregates of probe 3 and amino groups on spermidine determines the selective recognition of spermidine over other amines examined. The detection limit of probe 3 for spermidine was found to be 46 nM. Additionally, the utility of probe 3 for detection of spermidine in artificial urine sample and imaging of live HeLa cells has been demonstrated.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Polyamine; Aggregation; AIE; Terphenyl; Spermidine; Bioamine; Self-assembly
ID Code:114422
Deposited On:18 May 2018 10:32
Last Modified:18 May 2018 10:32

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