Chemotherapy of bacterial infections. Part III. Synthesis of (N4)-amino-substituted heterocyclic derivatives of sulphanilamide

Ganapathi, K. (1940) Chemotherapy of bacterial infections. Part III. Synthesis of (N4)-amino-substituted heterocyclic derivatives of sulphanilamide Proceedings of the Indian Academy of Sciences, Section A, 12 (3). pp. 274-283. ISSN 0370-0089

[img]
Preview
PDF - Publisher Version
1MB

Official URL: http://www.ias.ac.in/j_archive/proca/12/3/274-283/...

Related URL: http://dx.doi.org/10.1007/BF03173946

Abstract

The synthesis of thirteen (N4) amino-substituted sulphanilamide compounds of thiozal and related derivatives is described. None of them showed any activity in experimental streptococcal and pneumococcal infections in mice. Five sulphanilamide derivatives of acridine of the above group have also been described. Though some of them possessed considerable activity in the streptococcal infections, they were inactive in pneumococcal infections. It is apparent that for pronounced antibacterial action the heterocyclic ring should be substituted in the sulphonamide radical leaving a free amino group, which appears to play some significant, but as yet not perfectly understood, role in the mechanism of therapeutic action.

Item Type:Article
Source:Copyright of this article belongs to Indian Academy of Sciences.
ID Code:11423
Deposited On:09 Nov 2010 06:09
Last Modified:16 May 2016 20:53

Repository Staff Only: item control page