Characterization of the nonregular regions of proteins by a contortion index

De, Subhajyoti ; Sur, Kunal ; Dasgupta, Swagata (2005) Characterization of the nonregular regions of proteins by a contortion index Biopolymers, 79 (2). pp. 63-73. ISSN 0006-3525

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Nonstructured regions in proteins that provide the link between two regular structured regions play a significant role in maintaining the scaffold of the protein. Not only do they act as connectors between two regular secondary structural elements of proteins but they also provide the necessary turn or reversal in the polypeptide chain. This incorporates flexibility in the structure. Thus an understanding of the structural aspects of the nonregular regions is necessary to have a better insight into these features. We can assume the nonregular region to be a contorted polypeptide segment tethered by regular secondary structured regions at both ends. To describe the undulating nature of the nonregular regions, we introduce a parameter called the “contortion index.” This index describes how tortuously the region is organized. Our analysis shows that the contortion index is related to other physicochemical parameters and can be used to characterize the nonregular regions of proteins.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons, Inc.
Keywords:Nonregular Regions; Contortion Index; Amino Acid Propensities; Worm‐Like Chain Model
ID Code:113982
Deposited On:15 May 2018 07:06
Last Modified:15 May 2018 07:06

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