The t(8;14)(q24.1;q32) and its variant translocations: a study of 34 cases

Angi, Meenu ; Kamath, Vandana ; Yuvarani, S. ; Meena, J. ; Sitaram, Usha ; Manipadam, Marie Therese ; Nair, Sukesh ; Ganapule, Abhijeet ; Fouzia, N.A. ; Abraham, Aby ; Viswabandya, Auro ; Poonkuzhali, B. ; George, Biju ; Mathews, Vikram ; Srivastava, Alok ; Srivastava, Vivi M. (2017) The t(8;14)(q24.1;q32) and its variant translocations: a study of 34 cases Hematology/Oncology and Stem Cell Therapy, 10 (3). pp. 126-134. ISSN 1658-3876

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Background: The t(8;14)(q24.1;q32) and its variants – the t(2;8)(p12;q24.1) and t(8;22)(q24.1;q11.2) are associated with B-cell neoplasia and result in MYC/immunoglobulin (IG) gene rearrangement. Patients and methods: We correlated the cytogenetic, molecular and clinico-pathological findings of patients with 8q24 translocations seen in the Department of Haematology, Christian Medical College, Vellore, from January 2003 to December 2015. Results: There were 34 patients with 8q24 translocations (31, ALL and three myeloma). The t(8;14) was seen in 25 patients, t(8;22) in seven and t(2;8) in two. The salient findings were as follows: 85% males; 79% adults, median age 37 years; L3 morphology in 61%; mature B immunophenotype in 77%; extra-medullary disease in 41%; additional abnormalities in 28 (85%), notably, structural abnormalities of chromosome 1q (41%) and 13q (9%) and monosomy 13 (15%); complex karyotypes in 68%. There were two double-hit lymphoma/leukemia, one with a t(14;18)(q32;q21) and the other with a t(3;14)(q27;q11.2), associated with nodal high grade B cell lymphoma and dermal leukemic infiltrates respectively. Only 13 samples were processed for DNA PCR and all these samples were positive for MYC-IgH (c-gamma type) rearrangement. Only in one patient, in addition to c-gamma, c-alpha rearrangement was also detected. Conclusion: The frequency (1.7%) and distribution of these translocations in our series and the association with 1q and 13q abnormalities is similar to the literature. Trisomies 7 and 12 were seen in less than 10% of our patients.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:8q24 Translocations; Burkitt Leukemia/Lymphoma; Complex Karyotype; Double-Hit Leukemia/Lymphoma; MYC/Immunoglobulin Gene Rearrangement
ID Code:113913
Deposited On:07 Jun 2018 11:18
Last Modified:07 Jun 2018 12:15

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