A Cu-catalysed synthesis of substituted 3-methyleneisoindolin-1-one

Gogoi, Anupal ; Guin, Srimanta ; Rout, Saroj K. ; Majji, Ganesh ; Patel, Bhisma K. (2014) A Cu-catalysed synthesis of substituted 3-methyleneisoindolin-1-one RSC Advances, 4 (104). pp. 59902-59907. ISSN 2046-2069

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Official URL: http://pubs.rsc.org/en/content/articlelanding/2014...

Related URL: http://dx.doi.org/10.1039/C4RA12782J


A Cu(I)-catalysed synthesis of substituted 3-methyleneisoindolin-1-ones using alkynyl acids as an alkyne source has been developed. The reaction involves the decarboxylative cross-coupling of 2-halobenzamides with aryl alkynyl acids, followed by 5-exo-dig heteroannulation. While reactions of 2-iodo benzamides proceeded without a ligand, for 2-bromo substrates, the assistance of a ligand is essential.

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ID Code:113858
Deposited On:30 Apr 2018 12:11
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