A new route to prepare 6-chloro-5-(2-chloroethyl)oxindole

Gurjar, Mukund K. ; Murugaiah, A. M. S. ; Srinivasa Reddy, Dandepally (2003) A new route to prepare 6-chloro-5-(2-chloroethyl)oxindole Organic Process Research & Development, 7 (3). pp. 309-312. ISSN 1083-6160

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Official URL: http://pubs.acs.org/doi/abs/10.1021/op020095k

Related URL: http://dx.doi.org/10.1021/op020095k


6-Chloro-5-(2-chloroethyl)oxindole, a key intermediate in the manufacturing of the antipsychotic drug, ziprasidone, has been synthesized by a new route. The salient features of the synthesis are (1) bis-dialkylation of 2,4-difluoro-5-chloronitrobenzene with sodium diethyl malonate, (2) decarboxylative hydrolysis to obtain the oxindole derivative, and (3) reduction and chlorination of acetic ester side chain.

Item Type:Article
Source:Copyright of this article belongs to American Chemical Society.
ID Code:11384
Deposited On:09 Nov 2010 05:16
Last Modified:02 Jun 2011 09:49

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