N,N-dimethylacetamide (DMA) as a methylene synthon for regioselective linkage of imidazo[1,2-a]pyridine

Modi, Anju ; Ali, Wajid ; Patel, Bhisma K. (2016) N,N-dimethylacetamide (DMA) as a methylene synthon for regioselective linkage of imidazo[1,2-a]pyridine Advanced Synthesis & Catalysis, 358 (13). pp. 2100-2107. ISSN 1615-4150

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Official URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/ad...

Related URL: http://dx.doi.org/10.1002/adsc.201600067

Abstract

A copper(II)‐catalyzed oxidative methylene‐bridged dimerization of two analogous imidazo[1,2‐a]pyridines has been achieved using N,N‐dimethylacetamide (DMA) as solvent cum methylene source. This reaction works with a variety of substituted imidazo[1,2‐a]pyridines giving their products in moderate to good yields. Isotopic labelling experiments revealed that the methylene group in the product originates from the N,N‐dimethyl moiety of DMA.

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Deposited On:30 Apr 2018 12:14
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