Azido carbonyl compounds as DNA cleaving agents

Chowdhury, Nilanjana ; Dutta, Sansa ; Karthick, S. ; Anoop, Anakuthil ; Dasgupta, Swagata ; Pradeep Singh, N. D. (2012) Azido carbonyl compounds as DNA cleaving agents Journal of Photochemistry and Photobiology B: Biology, 115 . pp. 25-34. ISSN 1011-1344

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Irradiation of azido carbonyl compounds using UV light (≥310 nm) produced triplet alkyl nitrenes and aroyl radicals, which resulted in efficient cleavage of single strand DNA at pH 7.0. DNA cleaving ability of azido carbonyl compounds was found to be dependent on its concentration and substituents on its aromatic ring. Further, newly synthesized naphthalene based azido carbonyl compounds showed DNA cleavage ability at longer wavelength of UV light (≥350 nm) and also binding studies revealed that they bind to ct-DNA by weak intercalation mode.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Photoinduced DNA Cleavage; Azido Carbonyl Compound; Triplet Alkyl Nitrene; Aroyl Radical; DNA Binding
ID Code:113762
Deposited On:15 May 2018 11:30
Last Modified:15 May 2018 11:30

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