Development of Cd8α/α and Cd8α/β T cells in major histocompatibility complex class I–deficient mice

Das, Gobardhan ; Janeway, Charles A. (1999) Development of Cd8α/α and Cd8α/β T cells in major histocompatibility complex class I–deficient mice Journal of Experimental Medicine, 190 (6). pp. 881-884. ISSN 0022-1007

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Official URL: http://jem.rupress.org/content/190/6/881

Related URL: http://dx.doi.org/10.1084/jem.190.6.881

Abstract

Peripheral CD8+ T cells mainly use CD8α/β, and their development is mainly dependent on the major histocompatibility complex (MHC) class I proteins Kb and Db in H-2b mice. In this report, we have shown that the development of CD8α/β TCR-α/β cells in lymphoid organs as well as in intestinal intraepithelial lymphocytes (iIELs) is dependent on the MHC class I Kb and Db proteins. In contrast, TCR-α/β CD8α/α cells are found mainly in iIELs, and their numbers are unaffected in KbDb double knockout mice. Most of the TCR-γ/δ cells in the iIELs also bear CD8α/α, and they are also unaffected in KbDb −/− mice. In β2-microglobulin (β2m)-deficient mice, all of the TCR-α/β CD8α/α and CD8α/β T cells disappear, but TCR-γ/δ cells are unaffected by the absence of β2m.

Item Type:Article
Source:Copyright of this article belongs to Rockefeller University Press.
Keywords:CD8α/α T Cells; CD8α/β T Cells; Major Histocompatibility Complex Class I; KbDb-Deficient Mice; β2m-Deficient Mice
ID Code:113629
Deposited On:07 Jun 2018 05:10
Last Modified:07 Jun 2018 05:10

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