A practical synthesis of (R)-(−)-phenylephrine hydrochloride

Gurjar, Mukund K. ; Krishna, L. Murali ; Bugga, V. N. ; Sarma, B. S. ; Chorghade, Mukund S. (1998) A practical synthesis of (R)-(−)-phenylephrine hydrochloride Organic Process Research & Development, 2 (6). pp. 422-424. ISSN 1083-6160

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Official URL: http://pubs.acs.org/doi/abs/10.1021/op970128%2B

Related URL: http://dx.doi.org/10.1021/op970128+


(R)-(−)-Phenylephrine hydrochloride is a clinically potent adrenergic agent and B-receptor sympathomimetic drug, exclusively marketed in the optically active form. An asymmetric synthesis has been developed with high enantiomeric excess based on hydrolytic kinetic resolution of a styrene oxide derivative using (R,R)-SalenCoIIIOAc complex.

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ID Code:11355
Deposited On:09 Nov 2010 05:04
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