Fructose restrains fibrillogenesis in human serum albumin

Pandey, Nitin K. ; Ghosh, Sudeshna ; Dasgupta, Swagata (2013) Fructose restrains fibrillogenesis in human serum albumin International Journal of Biological Macromolecules, 61 . pp. 424-432. ISSN 0141-8130

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The endogenous deposition of protein aggregates with fibrillar morphology is known to govern the genesis of several neurodisorders. The investigation of naturally occurring small molecules which can restrict the fibrillation process can help in the design of rational therapeutics for neurodegenerative diseases. We report the inhibition of HSA fibrillation in the presence of naturally occurring sugars such as glucose, fructose, ribose and sucrose with fructose being the most potent. We have characterized the inhibitory potency of the sugars, using different spectroscopic and microscopic techniques.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Human Serum Albumin; Fibrillation; Sugars; Inhibition; Spectroscopy; Microscopy
ID Code:113385
Deposited On:15 May 2018 06:17
Last Modified:15 May 2018 06:17

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