Interfacial force-driven pattern formation during drying of Aβ (25–35) fibrils

Sett, Ayantika ; Bag, Sudipta ; Dasgupta, Swagata ; DasGupta, Sunando (2015) Interfacial force-driven pattern formation during drying of Aβ (25–35) fibrils International Journal of Biological Macromolecules, 79 . pp. 344-352. ISSN 0141-8130

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Pattern formation during evaporation of biofluids finds significant applications in the biomedical field for disease identification. Aβ (25–35) is the smallest peptide in the amyloid peptide family that retains the toxicity of a full length peptide responsible for Alzheimer's disease and is chosen here as the model solute. Drying experiments on substrates of varying wettability exhibit unique drying patterns of Aβ (25–35) fibrils visualized through fluorescence microscopy and transmission electron microscopy. The unique pattern formations can be interpreted as manifestations of the changes in the self-pinning mechanism with changes in wettability, which in some cases resembles the well-known coffee ring effect. Additionally, the delicate balance between the drag and capillary forces has been perturbed by initiating controlled rates of evaporation and probing their effects on the fibril patterning.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Amyloid β (25–35) Fibrils; Wettability; Pattern Formation
ID Code:113337
Deposited On:15 May 2018 06:13
Last Modified:15 May 2018 06:13

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