Autophagy: cancer’s friend or foe?

Bhutia, Sujit K. ; Mukhopadhyay, Subhadip ; Sinha, Niharika ; Das, Durgesh Nandini ; Panda, Prashanta Kumar ; Patra, Samir K. ; Maiti, Tapas K. ; Mandal, Mahitosh ; Dent, Paul ; Wang, Xiang-Yang ; Das, Swadesh K. ; Sarkar, Devanand ; Fisher, Paul B. (2013) Autophagy: cancer’s friend or foe? Advances in Cancer Research, 118 . pp. 61-95. ISSN 0065-230X

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The functional relevance of autophagy in tumor formation and progression remains controversial. Autophagy can promote tumor suppression during cancer initiation and protect tumors during progression. Autophagy-associated cell death may act as a tumor suppressor, with several autophagy-related genes deleted in cancers. Loss of autophagy induces genomic instability and necrosis with inflammation in mouse tumor models. Conversely, autophagy enhances survival of tumor cells subjected to metabolic stress and may promote metastasis by enhancing tumor cell survival under environmental stress. Unraveling the complex molecular regulation and multiple diverse roles of autophagy is pivotal in guiding development of rational and novel cancer therapies.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Autophagy; Cancer Metastasis; Tumor Dormancy; Cancer Stem Cells; Cancer Therapy
ID Code:112964
Deposited On:09 May 2018 08:44
Last Modified:09 May 2018 08:44

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