Effect of amyloids on the vesicular machinery: Implications for somatic neurotransmission

Das, Anand Kant ; Pandit, Rucha ; Maiti, Sudipta (2015) Effect of amyloids on the vesicular machinery: Implications for somatic neurotransmission Philosophical Transactions of the Royal Society of London - Series B: Biological Sciences, 370 (1672). Article ID 20140187. ISSN 0080-4622

Full text not available from this repository.

Official URL: http://rstb.royalsocietypublishing.org/content/370...

Related URL: http://dx.doi.org/10.1098/rstb.2014.0187


Certain neurodegenerative diseases are thought to be initiated by the aggregation of amyloidogenic proteins. However, the mechanism underlying toxicity remains obscure. Most of the suggested mechanisms are generic in nature and do not directly explain the neuron-type specific lesions observed in many of these diseases. Some recent reports suggest that the toxic aggregates impair the synaptic vesicular machinery. This may lead to an understanding of the neuron-type specificity observed in these diseases. A disruption of the vesicular machinery can also be deleterious for extra-synaptic, especially somatic, neurotransmission (common in serotonergic and dopaminergic systems which are specifically affected in Alzheimer's disease (AD) and Parkinson's disease (PD), respectively), though this relationship has remained unexplored. In this review, we discuss amyloid-induced damage to the neurotransmitter vesicular machinery, with an eye on the possible implications for somatic exocytosis. We argue that the larger size of the system, and the availability of multi-photon microscopy techniques for directly visualizing monoamines, make the somatic exocytosis machinery a more tractable model for understanding the effect of amyloids on all types of vesicular neurotransmission. Indeed, exploring this neglected connection may not just be important, it may be a more fruitful route for understanding AD and PD.

Item Type:Article
Source:Copright of the article belongs to The Royal Society.
ID Code:112953
Deposited On:24 May 2018 11:21
Last Modified:24 May 2018 11:21

Repository Staff Only: item control page