Dash, Rupesh ; Mandal, Mahitosh ; Ghosh, Sudip K. ; Kundu, S. C. (2008) Silk sericin protein of tropical tasar silkworm inhibits UVB-induced apoptosis in human skin keratinocytes Molecular and Cellular Biochemistry, 311 (1-2). pp. 111-119. ISSN 0300-8177
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Official URL: https://link.springer.com/article/10.1007/s11010-0...
Related URL: http://dx.doi.org/10.1007/s11010-008-9702-z
Abstract
The silk protein sericin has been identified as a potent antioxidant and photoprotective agent against Ultraviolet B (UVB) irradiation in mouse skin model. In this study, we have investigated the anti-apoptotic effect of sericin in UVB (30 mJ/cm2)-irradiated human keratinocytes. Flow cytometry analysis has shown that pre-treatment with sericin inhibits UVB-induced apoptosis. The pre-treatment with sericin suppresses bax expression, up-regulates the expression of bcl-2, prevents both the activation of caspase-3 and cleavage of Poly (ADP-ribose) polymerase. Generation of intracellular hydrogen peroxide in UVB-treated keratinocytes is inhibited through pre-treatment with sericin suggesting that sericin probably prevents mitochondrial damage.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Springer-Verlag. |
| Keywords: | Sericin; Keratinocytes; UVB; H2O2 |
| ID Code: | 112897 |
| Deposited On: | 08 May 2018 06:50 |
| Last Modified: | 08 May 2018 06:50 |
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