Nadkarni, G. D. ; B. Naik, Suvita ; Talavdekar, R. V. ; S. Soman, Chitralekha ; Ganatra, R. D. (1983) Potentiation of hepatotoxicity by ethanol in galactosamine-induced hepatitis in rats ¦ Role of propylthiouracil protection Acta Pharmacologica et Toxicologica, 52 (2). pp. 90-94. ISSN 0001-6683
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Official URL: http://www3.interscience.wiley.com/journal/1222328...
Related URL: http://dx.doi.org/10.1111/j.1600-0773.1983.tb03408.x
Abstract
Chronic ingestion of ethanol (5 g/kg/day)for 6 weeks increased the hepatotoxicity of a single injection of D-galactosamine (330 mg/kg) in rats. Plasma transaminases, alkaline phosphatase, gamma glutamyl transpeptidase and sulphobromophthalein retention were consistently high in alcohol-fed rats compared to sucrose-fed controls, 25 hours after galactosamine administraction. Liver histology in sucrose-fed rats revealed typical inflammatory changes and cytoplasmic vacuolation without cell necrosis was seen. Propylthiouracil treatment had no beneficial or protective effect in alcohol-fed rats in this animal model of hepatitis.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Nordic Pharmacological Society. |
| Keywords: | Galactosamine ; Liver Function ; Hepatotoxicity ; Alcohol ; Rats |
| ID Code: | 11257 |
| Deposited On: | 09 Nov 2010 03:43 |
| Last Modified: | 01 Jun 2011 12:03 |
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