Disappearance rate of endogenously radioiodinated thyroglobulin and thyroxine after radioiodine treatment

Abstract

Endogenously radioiodinated thyroglobulin (tg) and thyroxine (T₄), in the circulation following, therapeutic doses of radioiodine were studied in five patients with differentiated thyroid carcinoma. Radioactive serum was fractionated on a Sephadex G-200 and the various radioactive peaks thus obtained were analyzed for their biochemical and immunologic characteristics using precipitation with trichloroacetic acid (TCA) and antithyroglobulin antibody extraction with acidified n-butanol and electrophoresis on agar gel. The disappearance rates of endogenously labelled tg and T₄ were 3.12 ± 0.396 days and 10.14 ± 1.81 days, respectively.