Goitrogenic principle from castor seeds

Pahuja, D. N. ; Gavnekar, S. V. ; Shah, D. H. ; Jathar, V. S. ; Kulkarni, P. R. ; Ganatra, R. D. (1979) Goitrogenic principle from castor seeds Biochemical Pharmacology, 28 (5). pp. 641-643. ISSN 0006-2952

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/000629...

Related URL: http://dx.doi.org/10.1016/0006-2952(79)90148-5


Ricinine, a principal alkaloid isolated from the castor-cake, has been studied for its antithyroid activity. Its effect on goiter production and thyroid hormonogenesis has been compared with the known goitrogen, propylthiouracil. The data presented herein reveal that ricinine is a potent goitrogen.

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