Determination of absorption of vitamin B12 by a double isotope tracer technique

Ganatra, R. D. ; Sundaram, K. ; Desai, K. B. ; Gaitonde, B. B. (1965) Determination of absorption of vitamin B12 by a double isotope tracer technique Journal of Nuclear Medicine, 6 (6). pp. 459-464. ISSN 0161-5505

[img]
Preview
PDF - Publisher Version
498kB

Official URL: http://jnm.snmjournals.org/cgi/content/abstract/6/...

Abstract

A new simple method for the study of vitamin B12 absorption involving the use of two tracers is described. Along with 58Co labeled vitamin B12 an unabsorbable marker in the form of 51Cr labeled chromic oxide is administered to the patients. The ratio of the activities of the two isotopes in the standard is compared with the ratio of the activies of these isotopes in an aliquot of a stool sample collected after 24 or 48 hours. The absorption of labeled vitamin B12 is estimated from the alteration in the ratio of absorbable and unabsorbable isotopes in the stool sample. The method compares well with other methods of estimating vitamin B12 absorption such as Schilling's test, total faecal collection and whole body counting.

Item Type:Article
Source:Copyright of this article belongs to Society of Nuclear Medicine.
ID Code:11215
Deposited On:09 Nov 2010 03:47
Last Modified:16 May 2016 20:41

Repository Staff Only: item control page