Kumar, Vinod ; Brent, Jack R. ; Shorie, Munish ; Kaur, Harmanjit ; Chadha, Gaganpreet ; Thomas, Andrew G. ; Lewis, Edward A. ; Rooney, Aidan P. ; Nguyen, Lan ; Zhong, Xiang Li ; Burke, M. Grace ; Haigh, Sarah J. ; Walton, Alex ; McNaughter, Paul D. ; Tedstone, Aleksander A. ; Savjani, Nicky ; Muryn, Christopher A. ; O’Brien, Paul ; Ganguli, Ashok K. ; Lewis, David J. ; Sabherwal, Priyanka (2016) Nanostructured aptamer-functionalized black phosphorus sensing platform for label-free detection of myoglobin, a cardiovascular disease biomarker ACS Applied Materials & Interfaces, 8 (35). pp. 22860-22868. ISSN 1944-8244
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Official URL: http://pubs.acs.org/doi/abs/10.1021/acsami.6b06488
Related URL: http://dx.doi.org/10.1021/acsami.6b06488
Abstract
We report the electrochemical detection of the redox active cardiac biomarker myoglobin (Mb) using aptamer-functionalized black phosphorus nanostructured electrodes by measuring direct electron transfer. The as-synthesized few-layer black phosphorus nanosheets have been functionalized with poly-l-lysine (PLL) to facilitate binding with generated anti-Mb DNA aptamers on nanostructured electrodes. This aptasensor platform has a record-low detection limit (∼0.524 pg mL–1) and sensitivity (36 μA pg–1 mL cm–2) toward Mb with a dynamic response range from 1 pg mL–1 to 16 μg mL–1 for Mb in serum samples. This strategy opens up avenues to bedside technologies for multiplexed diagnosis of cardiovascular diseases in complex human samples.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| Keywords: | 2-D Materials; Aptamer; Black Phosphorus; Heart Disease; Myoglobin; Sensing |
| ID Code: | 112060 |
| Deposited On: | 28 Sep 2017 12:21 |
| Last Modified: | 28 Sep 2017 12:21 |
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