Anisotropic silica mesostructures for DNA encapsulation

Ganguly, Aparna ; Ganguli, Ashok K. (2013) Anisotropic silica mesostructures for DNA encapsulation Bulletin of Material science, 36 (2). pp. 329-332. ISSN 0250-4707

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The encapsulation of biomolecules in inert meso or nanostructures is an important step towards controlling drug delivery agents. Mesoporous silica nanoparticles (MSN) are of immense importance owing to their high surface area, large pore size, uniform particle size and chemical inertness. Reverse micellar method with CTAB as the surfactant has been used to synthesize anisotropic mesoporous silica materials. We have used the anisotropic silica nanostructures for DNA encapsulation studies and observed a loading capacity of ~ 8 μ g mg−1 of the sample. On functionalizing the pores of silica with amine group, the amount of DNA loaded on the rods decreases which is due to a reduction in the pore size upon grafting of amine groups.

Item Type:Article
Source:Copyright of this article belongs to Indian Academy of Sciences.
Keywords:Surfactant; Reverse Micellar Method; Silica Mesostructures; Surface Area
ID Code:111909
Deposited On:28 Sep 2017 12:22
Last Modified:28 Sep 2017 12:22

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