Gajendra, Smeeta ; Gupta, Ritu ; Chandgothia, Meenal ; Kumar, Lalit ; Gupta, Richa ; Chavan, Snehal Motilal (2014) Chronic neutrophilic leukemia with V617F JAK2 mutation Indian Journal of Hematology and Blood Transfusion, 30 (2). pp. 139-142. ISSN 0974-0449
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Official URL: https://link.springer.com/article/10.1007%2Fs12288...
Related URL: http://dx.doi.org/10.1007/s12288-012-0203-6
Abstract
Chronic neutrophilic leukemia (CNL) is a rare disease grouped under World health organization classification as chronic myeloproliferative disease. It is a diagnosis of exclusion in patients with sustained mature neutrophilia and splenomegaly with no evidence of other myeloproliferative disease or reactive neutrophilia. V617F JAK 2 mutation has been described in classical myeloproliferative diseases, but its association with CNL has been reported in a few cases. Here in, we describe three cases of CNL with presence of V617F JAK 2 mutation. To distinguish CNL from secondary neutrophilia can be difficult. Detection of the V617F JAK 2 mutation in such scenario can provide a useful diagnostic test to establish the neoplastic nature of the neutrophilia.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Springer Verlag. |
| Keywords: | Chronic Myeloproliferative Disease; Chronic Neutrophilic Leukemia; V617F JAK 2 Mutation |
| ID Code: | 111265 |
| Deposited On: | 25 Sep 2017 12:42 |
| Last Modified: | 25 Sep 2017 12:42 |
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