Chronic neutrophilic leukemia with V617F JAK2 mutation

Gajendra, Smeeta ; Gupta, Ritu ; Chandgothia, Meenal ; Kumar, Lalit ; Gupta, Richa ; Chavan, Snehal Motilal (2014) Chronic neutrophilic leukemia with V617F JAK2 mutation Indian Journal of Hematology and Blood Transfusion, 30 (2). pp. 139-142. ISSN 0974-0449

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Chronic neutrophilic leukemia (CNL) is a rare disease grouped under World health organization classification as chronic myeloproliferative disease. It is a diagnosis of exclusion in patients with sustained mature neutrophilia and splenomegaly with no evidence of other myeloproliferative disease or reactive neutrophilia. V617F JAK 2 mutation has been described in classical myeloproliferative diseases, but its association with CNL has been reported in a few cases. Here in, we describe three cases of CNL with presence of V617F JAK 2 mutation. To distinguish CNL from secondary neutrophilia can be difficult. Detection of the V617F JAK 2 mutation in such scenario can provide a useful diagnostic test to establish the neoplastic nature of the neutrophilia.

Item Type:Article
Source:Copyright of this article belongs to Springer Verlag.
Keywords:Chronic Myeloproliferative Disease; Chronic Neutrophilic Leukemia; V617F JAK 2 Mutation
ID Code:111265
Deposited On:25 Sep 2017 12:42
Last Modified:25 Sep 2017 12:42

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