Autoradiographic study of transcription and dosage compensation in the sex and neo-sex chromosome of Drosophila nasuta nasuta and Drosophila nasuta albomicans

Mahesh, G. ; Ramachandra, N. B. ; Ranganath, H. A. (2001) Autoradiographic study of transcription and dosage compensation in the sex and neo-sex chromosome of Drosophila nasuta nasuta and Drosophila nasuta albomicans Genome, 44 (1). pp. 71-78. ISSN 0831-2796

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Official URL: http://www.nrcresearchpress.com/doi/abs/10.1139/g0...

Abstract

Cellular autoradiography is used to study the transcription patterns of the polytene X chromosomes in Drosophila nasuta nasuta and D. n. albomicans. D. n. nasuta, with 2n = 8, includes a pair of complete heteromorphic sex chromosomes, whereas D. n. albomicans, with 2n = 6, has a pair of metacentric neo-sex chromosomes representing incomplete heteromorphic sex chromosomes. The neo-X chromosome has two euchromatic arms, one representing the ancestral X while the other represents the ancestral autosome 3 chromosomes. The metacentric neo-Y chromosome has one arm with a complete heterochromatic ancestral Y and the other arm with a euchromatic ancestral autosome 3. The transcription study has revealed that the X chromosome in D. n. nasutais hyperactive, suggesting complete dosage compensation, while in the neo-X chromosome of D. n. albomicans the ancestral X chromosome is hyperactive and the ancestral autosome 3, which is part of the neo-sex chromosome, is similar to any other autosomes. This finding shows dosage compensation on one arm (XLx/) of the neo-X chromosome, while the other arm (XR3/YR3) is not dosage compensated and has yet to acquire the dosage compensatory mechanism.

Item Type:Article
Source:Copyright of this article belongs to NRC Research Press (Canadian Science Publishing).
Keywords:Drosophila, Chromosomal Races, Neo-sex Chromosome, Transcription and Dosage Compensation
ID Code:111065
Deposited On:31 Jan 2018 11:40
Last Modified:31 Jan 2018 11:40

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