Khadilkar, Rohan J. ; Rodrigues, Diana ; Mote, Ridim Dadasaheb ; Sinha, Arghyashree Roychowdhury ; Kulkarni, Vani ; Magadi, Srivathsa Subramanya ; Inamdar, Maneesha S. (2014) ARF1–GTP regulates Asrij to provide endocytic control of Drosophila blood cell homeostasis Proceedings of the National Academy of Sciences, 111 (13). pp. 4898-4903. ISSN 0027-8424
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Official URL: http://www.pnas.org/content/111/13/4898
Related URL: http://dx.doi.org/10.1073/pnas.1303559111
Abstract
Ras small GTPases including ARFs act as molecular switches to modulate signaling pathways involved in hematopoiesis. Decreased guanine nucleotide exchange factor activity or increased GTPase-activating protein activation are associated with many leukemias, myelodysplastic syndromes, and myeloproliferative disorders. Drosophila is a good model to address questions related to aberrant hematopoiesis. Using Drosophila genetics and gene expression analysis we show tissue-specific function of the ubiquitously expressed endocytic protein, Drosophila ARF1 by interaction of ARF1–GTP with a blood-cell–expressed endocytic protein Asrij. The ARF1–Asrij axis brings about endosomal regulation of multiple signaling pathways in hematopoiesis.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to National Academy of Sciences. |
| ID Code: | 109223 |
| Deposited On: | 01 Feb 2018 04:56 |
| Last Modified: | 01 Feb 2018 04:56 |
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