Swaminathan, Sathyamangalam ; Khanna, Navin ; Herring, Belinda ; Mahalingam, Suresh (2013) Dengue vaccine efficacy trial: does interference cause failure? The Lancet Infectious Diseases, 13 (3). pp. 191-192. ISSN 1473-3099
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Official URL: http://www.thelancet.com/journals/laninf/article/P...
Related URL: http://dx.doi.org/10.1016/S1473-3099(13)70028-8
Abstract
Live-attenuated vaccines replicate at low concentrations and elicit protective immunity without causing disease. This strategy has proven to be successful when the vaccine targets one pathogen, as is the case for vaccines against yellow fever and Japanese encephalitis viruses1. Translation of this straightforward idea to target dengue has proven frustrating, because dengue is a complex flaviviral disease that is caused by not one, but four antigenically distinct dengue viruses (DENV-1, 2, 3 and 4).
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 109037 |
| Deposited On: | 09 Mar 2018 12:10 |
| Last Modified: | 09 Mar 2018 12:10 |
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