Post kala-azar dermal leishmaniasis: an unresolved mystery

Mukhopadhyay, Debanjan ; Dalton, Jane E. ; Kaye, Paul M. ; Chatterjee, Mitali (2014) Post kala-azar dermal leishmaniasis: an unresolved mystery Trends in Parasitology, 30 (2). pp. 65-74. ISSN 1471-4922

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/j.pt.2013.12.004

Abstract

Post kala-azar dermal leishmaniasis (PKDL), a cutaneous sequela of visceral leishmaniasis (VL), develops in some patients alongside but more commonly after apparent cure from VL. In view of the pivotal role of PKDL patients in the transmission of VL, here we review clinical, epidemiological, parasitological, and immunological perspectives of this disease, focusing on five hypotheses to explain the development of PKDL: (i) the role of antimonial drugs; (ii) UV-induced skin damage; (iii) reinfection; (iv) organ specific failure of memory T cell responses; and (v) genetic susceptibility of the host. This review will enable researchers and clinicians to explore the unresolved mystery of PKDL and provide a framework for future application of ‘omic’ approaches for the control and eventual elimination of VL.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Antimony; Post Kala-Azar Dermal Leishmaniasis; (PKDL)UV Light Vitamin D; regulatory T Cells
ID Code:108886
Deposited On:09 Mar 2018 11:47
Last Modified:09 Mar 2018 11:47

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