Mandal, Madhumita ; Kumar, Deepak ; Roy, Rajneeta ; Sen, Rupashree ; Das, Padma ; Chatterjee, Mitali ; Jaisankar, Parasuraman (2011) Regioselective one pot synthesis of 3,3′-diindolylethylene derivatives and study of their cytotoxic activity Bioorganic & Medicinal Chemistry Letters, 21 (10). pp. 3084-3087. ISSN 0960-894X
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.bmcl.2011.03.028
Abstract
2,2′-Diphenyl-3,3′-diindolylethylene (DPDIE) derivatives 3a–g were regioselectively prepared in one pot from indoles 1a–g in the presence of Lewis acids and were subsequently evaluated for cytotoxic activity against human leukemic cell lines, U937 and K562. The most potent compound 3g exhibited ICz50 of 13.0–17.0 μM.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Diindolyl Ethylene; Nitroethane; Friedel–Crafts Acylation; In vitro Cytotoxic Activity; MTS–PMS Assay |
| ID Code: | 108786 |
| Deposited On: | 09 Mar 2018 11:45 |
| Last Modified: | 09 Mar 2018 11:45 |
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