Das, Bimolendu ; Chowdhury, Chinmay ; Kumar, Deepak ; Sen, Rupashree ; Roy, Rajneeta ; Das, Padma ; Chatterjee, Mitali (2010) Synthesis, cytotoxicity, and structure–activity relationship (SAR) studies of andrographolide analogues as anti-cancer agent Bioorganic & Medicinal Chemistry Letters, 20 (23). pp. 6947-6950. ISSN 0960-894X
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.bmcl.2010.09.126
Abstract
A series of analogues of andrographolide, prepared through chemo-selective functionalization at C14 hydroxy, have been evaluated for in vitro cytotoxicities against human leukemic cell lines. Two of the analogues (6a, 9b) exhibited significant potency. Preliminary studies on structure–activity relationship (SAR) revealed that the α-alkylidene-γ-butyrolactone moiety of andrographolide played a major role in the activity profile. The structures of the analogues were established through spectroscopic and analytical data.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Andrographolide; C14-ester; Analogue; Anti-cancer; Apoptosis |
| ID Code: | 108785 |
| Deposited On: | 09 Mar 2018 11:46 |
| Last Modified: | 09 Mar 2018 11:46 |
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