Constrained flexibility in PNA: DNA binding studies with bridged aminopropylglycyl PNA

Lonkar, P. S. ; Kumar, V. A. ; Ganesh, K. N. (2001) Constrained flexibility in PNA: DNA binding studies with bridged aminopropylglycyl PNA Nucleosides, Nucleotides and Nucleic Acids, 20 (4-7). pp. 1197-1200. ISSN 1525-7770

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Related URL: http://dx.doi.org/10.1081/NCN-100002518

Abstract

Introduction of methylene bridges in aegPNA and apgPNA molecules give rise to cyclic five and six membered ring structures. Synthesis of a new six membered cyclic PNA monomer, aminopipecolyl PNA (pipPNA) is reported. Incorporation of pipPNA into PNA oligomers and comparative binding with target DNA sequences is studied.

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