Joshi, Rajendra R. ; Nagappa Ganesh, K. (1992) Chemical cleavage of plasmid DNA by Cu(II), Ni(II) and Co(III) desferal complexes Biochemical and Biophysical Research Communications, 182 (2). pp. 588-592. ISSN 0006-291X
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/000629...
Related URL: http://dx.doi.org/10.1016/0006-291X(92)91773-J
Abstract
It is demonstrated that the Cu(II), Co(III) and Ni(II) complexes of a siderophore chelating drug desferal cleave DNA, in contrast to the corresponding Fe(II) complex which does not bring about DNA scission. Hydroxy radical scavengers inhibit the cleavage reaction.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 10822 |
| Deposited On: | 09 Nov 2010 04:46 |
| Last Modified: | 31 May 2011 10:02 |
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